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Clenbuterol is a substituted phenylaminoethanol and a long-acting β-2 adrenergic agonist with sympathomimetic activity. Clenbuterol selectively binds to and activates β-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of smooth muscle. In addition, clenbuterol also stimulates central nervous system (CNS), and causes an increase in blood pressure and heart rate due to both β-2 and β-1 adrenergic activities. It is most commonly available as the hydrochloride salt, clenbuterol hydrochloride.Application: Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals' lungs. The drug is both a decongestant and a bronchodilator. A decongestant thins the blood to reduce blood pressure while a bronchodilator widens the vessels that carry oxygen, so the volume of oxygen in the blood increases. In some European and Latin American countries, clenbuterol is approved as an asthma drug for humans too. The drug can be used in bodybuilding and weight-loss programs. Uses of Clenbuterol in Food Although Clenbuterol is more modernly human use as a pharmacological stimulant, Many show animals such as dogs and horses are given Clenbuterol mixed into their feed as a drug to enhance the performance, muscle rearing, and appearance of show animals. Clenbuterol has been used by countries in Europe and US as a means of increasing leanness and protein content. By increasing the leanness and protein content, farmers are able to yield a higher quality of meat. Treatment of urinary incontinence Clenbuterol can be effective only when sfincter activity is preserved, which is proved by means of urodynamic tests. The authors determine the indications and contraindications of administration of celbuterol. Future trends The effects that clenbuterol can have on the heart and muscles will depend on how high a dose someone has been taking and for how long. The risks increase with the dose and duration. Those taking high doses can cause decrease in the size, weight, strength, and activity of the heart. It also has therapeutic Function Anti-asthmatic
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