introduction Methyldrostenone is an anabolic androsteroid composed of the active steroid hormone Methyldrostanolone. This is an anabolic steroid derived from DHT which is also a structurally altered form of drostenone. history Synthesis of metestosterone was first mentioned in the literature in 1956, when Syntex Corporation conducted research for the discovery of a compound with antitumor properties. It was first mentioned and elaborated on in a 1959 research journal article, which discussed its synthetic methods in more detail, validated its tumor suppressor properties, and noted that it is an "effective oral active anabolic agent that exhibits only weak androgenic activity." Subsequent measurements of the anabolic and androgenic activity of metestosterone were published in Androgen and anabolic drugs in Vida, an outdated but still standard reference, which stated that metestosterone has oral bioavailability methyltestosterone with 400% as anabolic and 20% as androgen, Produces a Q ratio of 20 (anabolic to androgen ratio), which is considered very high.