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USE Tianeptine sodium salt is a tricyclic antidepressant, and its antidepressant mechanism is different from traditional tricyclic antidepressants. It can increase the reuptake of 5-HT in the synaptic space, and may have the effect of improving the conduction of 5-HT neurons. No affinity for choline or adrenaline receptors. Antidepressant efficacy is similar to tricyclic, but tolerance is better than tricyclic. In animal experiments, it can increase the spontaneous activity of pyramidal cells in hippocampus and accelerate their recovery after function inhibition. Chemicalbook increased the reabsorption of serotonin by neurons in the cerebral cortex and hippocampus. The absorption of tineptine sodium in the digestive tract is rapid and complete. Rapid distribution, PPB up to 94%. It was metabolized completely in the liver by β-oxidation and N-demethylation, and the clearance of terminal T1/2 was short at 2.5h. A very small amount of the drug (8%) was excreted from the kidney, mainly its metabolites from the urine. Patients with renal insufficiency cleared T1/2 for an extended 1h.Email : salesexecutive1@yeah.net whatsapp: +8618931626169 wickr: lilywang CAS 161258-30-6,
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