Contact me: Email : salesperson66@yeah.net whatsapp: +8619832408762 wickr: fairyqf Skype:+8619832408762   Characteristic:

common name	Larazotide Acetate	English name	Larazotide acetate
CAS number	881851-50-9	molecular weight	785.88500

molecular formula	C 34 H 59 N 9 O 12

accurate mass	785.42800
PSA	360.55000
LogP	3.73650

Usage: Larazotide acetate is an intestinal tight-junction regulator drug , previously known as Innovate Biopharmaceuticals before a merger,that is currently being tested in adult patients with celiac disease in a phase III clinical trial . This single-chain peptide is derived from human zonulin, a known modulator of tight junction permeability that has elevated intestinal tissue expression in patients with celiac disease . LA also shares structural similarities to the Vibrio cholerae zonula occludens toxin (Zot),   which is an enterotoxin that disrupts intercellular tight junction structure through actin polymerization and cytoskeletal modifications that result in increased intestinal permeability through intracellular signaling . Although LA has shown promise in clinical trials for patients with celiac disease,   recent studies using various animal injury models indicate a potential use for LA for other diseases because of its ability to regulate tight junctions.     This mini-review aims to provide a detailed source of current information on this octapeptide.