Contact me: Email : salesperson66@yeah.net whatsapp: +8619832408762 wickr: fairyqf Skype:+8619832408762   Characteristic:

Common name	Hexapeptide-11	English name	Hexapeptide-11
CAS number	161258-30-6

Molecular formula	C 36 H 48 N 6 O 7
Molecular weight	676.80200
Accurate mass	676.35800
PSA	201.71000
LogP	4.09300

  Usage: Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. Hexapeptide-11 reduces the appearance of fine lines and wrinkles, making this an excellent addition to all kinds of skin care and anti-aging products. It has a unique set of amino acids that help to manipulate collagen levels and boost elasticity in the skin. Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses related genes. Moreover, it promoted increased nuclear accumulation of Nrf2; higher expression levels of proteasomal protein subunits and increased proteasome peptidase activities. In line with these findings we noted that Hexapeptide-11 conferred significant protection in fibroblasts against oxidative-stress-mediated premature cellular senescence, while at in vivo skin deformation assays in human subjects it improved skin elasticity.