Etonitat and its related opioid agonist benzimidazole were discovered in the late 1950s by a team of Swiss researchers working at the pharmaceutical company CIBA (now Novartis). One of the first compounds studied by the Swiss team was 1-(beta-diethylaminoethyl) -2-benzyl benzimidazole, which was found to have 10% of morphine's analgesic activity in rodent bioassometry. This finding encouraged the team to begin a comprehensive systematic study of 2-benzyl benzimidazole and to establish the structural-activity relationship for this new family of painkillers. Two general synthesis methods were developed to prepare these compounds. The first method involves the condensation of o-phenylenediamine with phenylacetonitrile to form 2-benzylbenzimidazole. The benzimidazole is then alkylated with the desired 1-chloro-2-dialkyl aminoethane to form the final product. This particular method is most useful for preparing benzimidazole without substituents on the benzene ring The most general synthesis [4] developed by the Swiss team first involves the alkylation of 2, 4-dinitrochlorobenzene with 1-amino-2-diethylaminoethane to form N-(β-diethylaminoethyl)-2, 4-dinitroaniline [aka: N'- (2, 4-dinitrophenyl) -n, n-diethyl-ethane-1, 2-diamine]. The 2-nitro substituents on 2, 4-dinitroaniline compounds are then selectively reduced to corresponding primary amines by using ammonium sulfide as reducing agent. Ammonium sulfide can form hydrogen sulfide gas in situ by adding a concentrated ammonium hydroxide solution and saturating it with the solution. An intermediate formed by the selective reduction of 2-nitro-substituent 2-(β-diethylaminoethyl aminoethyl) -5-nitroaniline, which then reacts with the iminoethyl ether hydrochloride of 4-ethoxy phenylacetonitrile (aka: p-ethoxy benzyl cyanide). Iminoether, 2-(4-ethoxy phenyl) -acetyliminoate ethyl ester hydrochloride, is prepared as a gas by dissolving 4-substituted benzyl cyanide in a mixture of anhydrous ethanol and chloroform, and then saturating the solution with anhydrous hydrogen chloride. The reaction between 2-(beta-dialkyl aminoalkyl amine) -5-nitroaniline and the hydrochloride of iminoethyl ether results in the formation of etonitrazine. The procedure is particularly suitable for the preparation of 4-, 5-, 6- and 7-nitrobenzimidazole. The selection of altered substituted iminoethers of phenylacetic acid can provide compounds with multiple substituents at the benzene 2-site Many analogues are known, the only other notable compound derived from the original study in the 1950s is clonitacetone, which is much weaker than etonissini (about 3 times morphine). More recently, since around the end of 2018, a number of designer analogues have started to appear on the illegal market around the world, with the most prominent compounds being metronidazole, isonidazole and ettazine, but others continue to appear

FAQ

1.Can we get your free samples?

Yes, can. Our free sample can be provided for customers test. But the freight for express is on buyer's account.

2.Can we do printing or label on the bottles?
Yes, can. We can offer various printing ways,such, screen printing, hot stamping, label printing.

3.What is the normal lead time?

For stock products, within 24-48 hours after we receive your payment. For smaller customize color bottles, we will ship out within 3-5 days.

4.What is your shipping terms?
Faster ways: FDEX, DHL, UPS, TNT, etc by sea or by air economy

5.How does your factory do regarding quality control?

We do test for 3 times before packing.

6.MOQ

We don't have the minimum quantity,all ok,1mg,1g,1kg and so on,Please add my whatsapp,we can talk more,+8618931626169

Warning: Any man-made damage we cannot change, refund.

Contact me:

Email:salesexecutive1@yeah.net

Etomethazene CAS: 911-65-9 painkiller

Products Details

Contact me:

Email:salesexecutive1@yeah.net

Whatsapp:+8618931626169

Wickr:lilywang

Featured Products

Contact us