Peptide hormones are critical components of the endocrine system, regulating several physiological processes. Sincalide, also known as CCK-8, is one such peptide hormone that has drawn attention for its roles in gastrointestinal functions. With a molecular formula of C49H62N10O16S3 and a molecular weight of 1143.29 Dalton, Sincalide has become an important subject of research in the field of gastroenterology.
Sincalide is a synthetic octapeptide hormone that mimics the actions of natural Cholecystokinin (CCK), released by the enteroendocrine cells in the small intestine in response to food ingestion. CCK is responsible for signaling the gallbladder to secrete bile, which aids in the digestion of fats. It also stimulates pancreatic acinar cells to release digestive enzymes, pancreatic bicarbonate, and activates pancreatic sphincter to allow pancreatic exocrine enzymes to reach the duodenum to participate in food digestion. The gastrointestinal effects of Sincalide are similar, which makes it a useful diagnostic agent in certain medical procedures like gallbladder ultrasound, pancreatic function testing, and HIDA scan.
As a diagnostic agent, Sincalide is used to test the function of the gallbladder and the sphincters that control the flow of bile and pancreatic juice. In a gallbladder ultrasound, Sincalide is administered to the patient intravenously, and its effects are monitored by ultrasound to evaluate the gallbladder emptying ability. This test is vital in diagnosing conditions such as biliary dyskinesia, gallstones, and cholecystitis. Similarly, in pancreatic function testing, Sincalide is used to stimulate pancreatic enzyme secretion to assess exocrine pancreatic functions. In HIDA scan, Sincalide is administered to examine the bile duct and gallbladder for any blockages or other issues.
Hebei Zhanshun Technology Co., Ltd., is a company that specializes in the production and exportation of applied chemical raw materials. With their years of experience, they are known for delivering high-quality products and excellent customer service. The company has a registered capital of 10 million yuan and is legally licensed to produce many kinds of chemicals. In line with this, Hebei Zhanshun Technology Co., Ltd. is committed to adhering to strict quality standards, making sure all chemicals produced are of the highest quality.
In conclusion, Sincalide is a valuable tool in the medical field for diagnosing various gastrointestinal conditions. Its synthetic nature and similar effects to natural CCK make it a convenient diagnostic agent that plays an essential role in the diagnosis and treatment of various gastrointestinal disorders. With companies like Hebei Zhanshun Technology Co., Ltd., producing and supplying high-quality chemicals, the medical industry can rely on Sincalide to aid in their diagnostic procedures.